class B basic helix-loop-helix protein 3; bHLHB3; differentially expressed in chondrocytes protein 2; hDEC2; enhancer-of-split & hairy-related protein 1; SHARP-1 (BHLHB3, BHLHE41)

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^[1]^[2]

Function

transcriptional repressor
represses both basal & activated transcription

Structure

homodimer
contains 1 basic helix-loop-helix (bHLH)
contains 1 Orange domain

Compartment

Expression

-expressed in skeletal muscle & brain > pancreas & heart > placenta, lung, liver & kidney

Polymorphism

transcriptional repressor DEC2 regulates sleep length in mammals^[2]
- hDEC2-P385R that is associated with a human short sleep phenotype
  - 5 hours sleep may be sufficient

More general terms

transcriptional silencer (transcriptional repressor)

References

↑ UniProt http://www.uniprot.org/uniprot/Q9C0J9.html
↑ ^2.0 ^2.1 He Y, Jones CR, Fujiki N et al The Transcriptional Repressor DEC2 Regulates Sleep Length in Mammals. Science 2009. 325(5942):866-870 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19679812 PMCID: PMC2884988 Free PMC article https://science.sciencemag.org/content/325/5942/866

Database

OMIM: https://mirror.omim.org/entry/606200
UniProt: http://www.uniprot.org/uniprot/Q9C0J9.html

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