NGFI-A-binding protein 1 (EGR-1-binding protein 1, transcriptional regulatory protein p54, NAB1)

Function

• transcriptional repressor for zinc finger transcription factors EGR1 & EGR2
• homomultimers may associate with EGR1 bound to DNA
• NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain & mediates multimerization.
• NAB conserved domain 2 (NCD2) is necessary for transcriptional repression

Compartment

nucleus

Alternative splicing

named isoforms=2

Pathology

• short isoform is found in a myeloid leukemia cell line

More general terms

• transcriptional silencer (transcriptional repressor)

Database

• OMIM: https://mirror.omim.org/entry/600800
• UniProt: http://www.uniprot.org/uniprot/Q13506.html