NGFI-A-binding protein 2; EGR-1-binding protein 2; melanoma-associated delayed early response protein; MADER protein (NAB2, MADER)

Function

• transcriptional repressor for EGR1, EGR2
• isoform 2 lacks transcriptional repressor activity
• homomultimers may associate with EGR1 bound to DNA

Compartment

• nucleus
• isoform 2 is not localized to the nucleus

Alternative splicing

named isoforms=3

Expression

• widely expressed at low levels
• highly expressed in melanoma cell lines

More general terms

• transcriptional silencer (transcriptional repressor)

Database

• OMIM: https://mirror.omim.org/entry/602381
• UniProt: http://www.uniprot.org/uniprot/Q15742.html