cellular nucleic acid-binding protein; CNBP; zinc finger protein 9 (CNBP, RNF163, ZNF9)

Function

• single stranded DNA-binding protein, with specificity for the sterol regulatory element (SRE)
• role in sterol-mediated repression

Structure

contains 7 CCHC-type Zn+2 fingers

Compartment

• cytoplasm (putative)
• endoplasmic reticulum (putative)

Alternative splicing

named isoforms=3

Expression

present in all tissues examined

Pathology

• defects in CNBP are the cause of myotonic dystrophy 2

More general terms

• DNA-binding protein
• transcriptional silencer (transcriptional repressor)
• zinc finger protein

Additional terms

• CNBP gene mutation; ZNF9 gene mutation

Database

• UniProt: http://www.uniprot.org/uniprot/P62633.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7555
• OMIM: https://mirror.omim.org/entry/116955
• OMIM: https://mirror.omim.org/entry/602668