natural resistance-associated macrophage protein 2 (NRAMP2, divalent metal transporter 1, DMT1, solute carrier family 11 member 2, SLC11A2, OK/SW-cl20)

Function

• macrophage-specific membrane transport
• important in metal transport, in particular iron

Structure

belongs to the NRAMP family

Compartment

membrane (probable)

Alternative splicing

named isoforms=2

Expression

expressed at low levels in all tissues analyzed

Pathology

• defects in SLC11A2 are a cause of hypochromic microcytic anemia
• mutations in SLC11A2 are associated with progressive liver iron overload & normal to moderately elevated serum ferritin levels

More general terms

• natural resistance-associated macrophage protein (Nramp)
• solute carrier family 11 (SLC11, SLC11A)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4891
• OMIM: https://mirror.omim.org/entry/206100
• OMIM: https://mirror.omim.org/entry/600523
• UniProt: http://www.uniprot.org/uniprot/P49281.html