transcobalamin-1; TC-1; transcobalamin I; cobalophilin R; R-binder; TC I; TCI (TCN1 TC1)
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Function
- binds to vit B12 in saliva protecting vit B12 in the acidic environment of the stomach
- in the duodenum, transcobalamin-1 releases vit B12 for binding to intrinsic factor
- transcobalamin-1 is the major reservoir of plasma cobalamin; it is typically 70-90% saturated
- plasma cobalamin bound to transcobalamin-1 is proababy metabolically inert since no cellular receptors for it have been identified
- transports cobalamin into cells[4]
- R-binder may be identical to transcobalamin-3 except for carbohydrate content
Structure
- contains about 30% carbohydrates
- belongs to the eukaryotic cobalamin transport protein family
Compartment
- found in plasma, amniotic fluid, milk, saliva, ascitic fluid, & granulocytes
Expression
neutrophil granule protein
Pharmacokinetics
- elimination 1/2life of the transcobalamin-1/vit B12 complex in plasma is 1 hour
Laboratory
- alias cobolaphilin R for rapidly migrating on electrophoresis
More general terms
More specific terms
References
- ↑ Clinical Diagnosis & Management by Laboratory Methods, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1991, pg 632
- ↑ Harrison's Online, Chapter 107, McGraw Hill, 2002
- ↑ Carmel R Clinical Chemistry. 48:407-409. 2002 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/11861432 <Internet> http://www.clinchem.org/cgi/content/full/48/3/407?ijkey=793472d270daf818b0942b60af4b1ef7f4b997cc&keytype2=tf_ipsecsha
- ↑ 4.0 4.1 UniProt http://www.uniprot.org/uniprot/P20061.html