serine/threonine/tyrosine-interacting protein; protein tyrosine phosphatase-like protein (STYX)

Function

• probable pseudophosphatase
• contains a Gly instead of a conserved Cys in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase
• the binding pocket is however sufficiently preserved to bind phosphorylated substrates, & maybe protect them from phosphatases
• seems to play a role in spermatogenesis
• interacts with CARHSP1/Crhsp-24 (putative)

Structure

• belongs to the protein-tyrosine phosphatase family non-receptor class subfamily
• contains 1 tyrosine-protein phosphatase domain

More general terms

• chaperonin; chaperone
• phosphatase inhibitor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=100290
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6815
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:100290
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6815
• UniProt: http://www.uniprot.org/uniprot/Q8WUJ0.html