double C2-like domain-containing protein alpha (Doc2-alpha, Doc2, DOC2A)

Function

• role in Ca+2 dependent neurotransmitter release via interaction with UNC13A
• role in dynein-dependent intracellular vesicle transport (putative)
• in vitro, binds Ca+2 & phospholipids via C2 domain 1
• interacts with cytoplasmic dynein light chain TCTEL1/TCTEX1

Structure

• contains 2 C2 domains

Compartment

• cytoplasmic vesicle, secretory vesicle, synaptic vesicle
• membrane

Expression

expressed in brain, testis

More general terms

• Ca+2 binding protein

Database

• OMIM: https://mirror.omim.org/entry/604567
• UniProt: http://www.uniprot.org/uniprot/Q14183.html