cell growth regulator with EF hand domain protein 1; cell growth regulatory gene 11 protein; hydrophobestin (CGREF1, CGR11)

Function

• inhibits cell growth of several cell lines
• mediates cell-cell adhesion (Ca+2-dependent)
• probably metabolized extracellularly by an unknown serine protease generating extremely hydrophobic bioactive peptides

Structure

• contains 2 EF-hand domains
• both EF-hands are required for function (putative)

Compartment

secreted (putative)

Expression

induced by p53

More general terms

• Ca+2 binding protein
• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10669
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10669
• OMIM: https://mirror.omim.org/entry/606137
• UniProt: http://www.uniprot.org/uniprot/Q99674.html