mannosyl-oligosaccharide 1,2-alpha-mannosidase 1C; HMIC; mannosidase alpha class 1C member 1; processing alpha-1,2-mannosidase 1C; alpha-1,2-mannosidase 1C (MAN1C1, MAN1A3, MAN1C)

Function

• protein modification; protein glycosylation
• maturation of Asn-linked oligosaccharides (N-glycosylation)
• trims alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc & a small amount of Man(5)GlcNAc
• hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)
• inhibited by both 1-deoxymannojirimycin & kifunensine

Cofactor: Ca+2

Structure

belongs to the glycosyl hydrolase 47 family

Compartment

• Golgi membrane
• single-pass type 2 membrane protein

Expression

• expressed in most tissues except lung, muscle, pancreas
• highly expressed in placenta

More general terms

• glycosidase (glycoside hydrolase)
• Ca+2 binding protein
• glycoprotein
• membrane protein
• phosphoprotein

Additional terms

• Asn glycosylation

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57134
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57134
• UniProt: http://www.uniprot.org/uniprot/Q9NR34.html