nucleobindin-2; DNA-binding protein NEFA; gastric cancer antigen Zg4 (NUCB2 NEFA)

Function

• Ca+2-binding protein
• may have a role in Ca+2 homeostasis

Structure

• belongs to the nucleobindin family
• contains 2 EF-hand domains

Compartment

• membrane; peripheral membrane protein
• cytoplasm
• secreted

Alternative splicing

named isoforms=2

Expression

• predominantly expressed in spleen, testis & normal stomach

Polymorphism

deletion of Gln-402 is frequent

Notes

• NEFA stands for N=DNA-binding; EF=EF-hand; A=acidic region

More general terms

• DNA-binding protein
• Ca+2 binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/P80303.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4925
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4925
• OMIM: https://mirror.omim.org/entry/608020