gamma-glutamyltransferase-5 (GGTLA1, GGT5)

Function

• cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself
• converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4)
• glutathione metabolism
• leukotriene metabolism, 2nd step

(5-L-glutamyl)-peptide + an amino acid
               <-->
peptide + 5-L-glutamyl amino acid

Structure

• heterodimer composed of the light & heavy chains
• active site is located in the light chain (putative)
• belongs to the gamma-glutamyltransferase family

Compartment

membrane

Alternative splicing

named isoforms=2

More general terms

• gamma-glutamyltransferase (GGT) or gamma-glutamyltranspeptidase

Database

• UniProt: http://www.uniprot.org/uniprot/P36269.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2687
• OMIM: https://mirror.omim.org/entry/137168