collagen 14 alpha-1 (undulin, COL14A1)

Function

• adhesion by integrating collagen bundles

Structure

• homotrimer
• belongs to the fibril-associated collagens with interrupted helices (FACIT) family
• contains 8 fibronectin F3 modules
• contains 1 TSP N-terminal (TSPN) domain
• contains 2 VWFA domains
• associated with surface of interstitial collagen fibrils via COL1 domain (putative)
• COL2 domain serves as a rigid arm which sticks out from the fibril & protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (putative)
• large N-terminal globular interacts with other matrix molecules or cell surface receptors (putative)
• Lys at the 3rd position of the G-X-Y tripeptide repeats are hydroxylated; they bind carbohydrates
• Pro at the 3rd position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains
• may contain numerous Cys involved in intermolecular & intramolecular disulfide bonding

Compartment

secreted

Alternative splicing

named isoforms=3

More general terms

• collagen subunit
• oligomerizing protein

Database

• OMIM: https://mirror.omim.org/entry/120324
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7373
• UniProt: http://www.uniprot.org/uniprot/Q05707.html