choline-phosphate cytidylyltransferase A; CCT-alpha; CTP:phosphocholine cytidylyltransferase A; CCT A; CT A; phosphorylcholine transferase A (PCYT1A, CTPCT, PCYT1)

Function

• controls phosphatidylcholine synthesis
• phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2
• Ser of the C-terminus are phosphorylated
• inactive soluble form is stabilized by phosphorylation, the active membrane bound form is promoted by anionic lipids or diacylglycerol, & is stabilized by dephosphorylation

CTP + choline phosphate = diphosphate + CDP-choline

Structure

• homodimer; disulfide-linked
• belongs to the cytidylyltransferase family

Compartment

• cytoplasm, cytosol (putative)
• peripheral membrane
• interconverts between an inactive cytosolic form & an active membrane-bound form (putative)

More general terms

• nucleotidyltransferase
• oligomerizing protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5130
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5130
• OMIM: https://mirror.omim.org/entry/123695
• UniProt: http://www.uniprot.org/uniprot/P49585.html