thymidine phosphorylase; TP; gliostatin; platelet-derived endothelial cell growth factor; PD-ECGF; TdRPase (TYMP, ECGF1)

Function

• may have a role in maintaining integrity of blood vessels
• growth promoting activity on endothelial cells, angiogenic activity in vivo & chemotactic activity on endothelial cells in vitro
• catalyzes reversible phosphorolysis of thymidine
  • the produced molecules are utilized as carbon & energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
• pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2

thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate

Structure

• homodimer
• belongs to the thymidine/pyrimidine-nucleoside phosphorylase family

Pathology

• defects in TYMP are the cause of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)

More general terms

• kinase or ATP-phosphotransferase
• oligomerizing protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1890
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1890
• OMIM: https://mirror.omim.org/entry/131222
• OMIM: https://mirror.omim.org/entry/603041
• UniProt: http://www.uniprot.org/uniprot/P19971.html