cytochrome b-c1 complex subunit 7; complex III subunit 7; complex III subunit VII; QP-C; ubiquinol-cytochrome c reductase complex 14 kD protein (UQCRB, UQBP)

Function

• component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), a component of the mitochondrial respiratory chain
• involved in redox-linked proton pumping

Structure

belongs to the UQCRB/QCR7 family

Compartment

mitochondrial inner membrane

Pathology

• defects in UQCRB are a cause of mitochondrial complex III deficiency

Notes

• originally thought to be the ubiquinone-binding protein

More general terms

• protein subunit
• mitochondrial membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7381
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7381
• OMIM: https://mirror.omim.org/entry/124000
• OMIM: https://mirror.omim.org/entry/191330
• UniProt: http://www.uniprot.org/uniprot/P14927.html