cytochrome b-c1 complex subunit 8; complex III subunit 8; complex III subunit VIII; ubiquinol-cytochrome c reductase complex 9.5 kD protein; ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C (UQCRQ)

Function

• component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), a component of the mitochondrial respiratory chain
• together with cytochrome b, binds to ubiquinone

Structure

belongs to the UQCRQ/QCR8 family

Compartment

mitochondrial inner membrane

Pathology

• defects in UQCRQ are a cause of mitochondrial complex III deficiency

More general terms

• protein subunit
• mitochondrial membrane protein

Component of

• ubiquinol cytochrome c reductase; respiratory complex 3

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27089
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27089
• OMIM: https://mirror.omim.org/entry/124000
• OMIM: https://mirror.omim.org/entry/612080
• UniProt: http://www.uniprot.org/uniprot/O14949.html