NADH dehydrogenase subunit-5 (MT-ND5)

Function

• subunit of NADH dehydrogenase (mitochondrial complex 1)

NADH + ubiquinone <--> NAD+ + ubiquinol

Structure

belongs to the complex 1 subunit 5 family

Compartment

mitochondrial inner membrane

Pathology

• defects in MT-ND5 are a cause of
  • Leber hereditary optic neuropathy
  • myoclonic epilepsy associated with ragged-red fibers (MERRF)
  • Leigh syndrome
  • complex 1 mitochondrial respiratory chain deficiency
  • MELAS syndrome

Laboratory

• MT-ND5 gene mutation

More general terms

• NADH dehydrogenase subunit
• flavoprotein

Component of

• NADH dehydrogenase; respiratory chain complex-I; NADH CoQ reductase;NADH-ubiquinone oxidoreductase

Database

• UniProt: http://www.uniprot.org/uniprot/P03915.html
• OMIM: https://mirror.omim.org/entry/252010
• OMIM: https://mirror.omim.org/entry/256000
• OMIM: https://mirror.omim.org/entry/516005
• OMIM: https://mirror.omim.org/entry/535000
• OMIM: https://mirror.omim.org/entry/540000
• OMIM: https://mirror.omim.org/entry/545000