NADH dehydrogenase subunit-3 (MT-ND3)

Function

• subunit of NADH dehydrogenase (mitochondrial complex 1)

NADH + ubiquinone <--> NAD+ + ubiquinol

Structure

belongs to the complex 1 subunit 3 family

Compartment

mitochondrial inner membrane

Pathology

• defects in MT-ND3 are a cause of
  • Leigh syndrome
  • complex 1 mitochondrial respiratory chain deficiency

More general terms

• NADH dehydrogenase subunit
• flavoprotein

Component of

• NADH dehydrogenase; respiratory chain complex-I; NADH CoQ reductase;NADH-ubiquinone oxidoreductase

Database

• UniProt: http://www.uniprot.org/uniprot/P03897.html
• OMIM: https://mirror.omim.org/entry/252010
• OMIM: https://mirror.omim.org/entry/256000
• OMIM: https://mirror.omim.org/entry/516002