NADH dehydrogenase subunit-2 (MT-ND2)

Function

• subunit of NADH dehydrogenase (mitochondrial complex 1)

NADH + ubiquinone <--> NAD+ + ubiquinol

Structure

belongs to the complex 1 subunit 2 family

Compartment

mitochondrial inner membrane

Pathology

• defects in MT-ND2 are a cause of
  • Leber hereditary optic neuropathy
  • mitochondrial susceptibility to Alzheimer disease

More general terms

• NADH dehydrogenase subunit
• flavoprotein

Component of

• NADH dehydrogenase; respiratory chain complex-I; NADH CoQ reductase;NADH-ubiquinone oxidoreductase

Database

• UniProt: http://www.uniprot.org/uniprot/P03891.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4536
• OMIM: https://mirror.omim.org/entry/502500
• OMIM: https://mirror.omim.org/entry/516001
• OMIM: https://mirror.omim.org/entry/535000