NADH dehydrogenase subunit-1 (NADH ubiquinone oxidoreductase chain-1, MT-ND1, MTND1, NADH1, ND1)

Function

• component of NADH dehydrogenase (mitochondrial complex 1)

NADH + ubiquinone <--> NAD+ + ubiquinol

Structure

belongs to the complex 1 subunit 1 family

Compartment

mitochondria inner membrane

Pathology

• defects in MT-ND1 are a cause of
  • Leber hereditary optic neuropathy
  • MELAS syndrome
  • mitochondrial susceptibility to Alzheimer disease
  • non-insulin-dependent diabetes mellitus (NIDDM)

More general terms

• flavoprotein
• NADH dehydrogenase subunit

Component of

• NADH dehydrogenase; respiratory chain complex-I; NADH CoQ reductase;NADH-ubiquinone oxidoreductase

Database

• UniProt: http://www.uniprot.org/uniprot/P03886.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4535
• OMIM: https://mirror.omim.org/entry/502500
• OMIM: https://mirror.omim.org/entry/516000
• OMIM: https://mirror.omim.org/entry/535000
• OMIM: https://mirror.omim.org/entry/540000