NADH dehydrogenase 49 kD subunit, mitochondrial-encoded (complex 1-49KD, NADH ubiquinone oxidoreductase subunit FeS protein 2, NDUFS2)

Function

• core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex 1)
• component of minimal assembly required for catalysis

Cofactor: binds 1 4Fe-4S cluster

Structure

belongs to the complex 1 49 kD subunit family

Compartment

mitochondrial inner membrane; matrix side

Pathology

• defects in NDUFS2 are a cause NADH dehydrogenase deficiency

More general terms

• flavoprotein
• NADH dehydrogenase subunit

Component of

• NADH dehydrogenase; respiratory chain complex-I; NADH CoQ reductase;NADH-ubiquinone oxidoreductase

Database

• UniProt: http://www.uniprot.org/uniprot/O75306.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4720
• OMIM: https://mirror.omim.org/entry/252010
• OMIM: https://mirror.omim.org/entry/602985