NADH dehydrogenase 18 kD subunit, mitochondrial-encoded (complex 1-18KD, complex 1-AQDQ, NADH ubiquinone oxidoreductase subunit FeS protein 4, NDUFS4)

Function

• accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex 1)
• not involved in catalysis
• component of the iron-sulfur (IP) fragment of complex 1

Structure

belongs to the complex 1 NDUFS4 subunit family

Compartment

mitochondrial inner membrane, matrix side

Pathology

• defects in NDUFS4 are a cause of NADH dehydrogenase deficiency

More general terms

• NADH dehydrogenase subunit
• phosphoprotein

Component of

• NADH dehydrogenase; respiratory chain complex-I; NADH CoQ reductase;NADH-ubiquinone oxidoreductase

Database

• UniProt: http://www.uniprot.org/uniprot/O43181.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4724
• OMIM: https://mirror.omim.org/entry/252010
• OMIM: https://mirror.omim.org/entry/602694