P2X1 purinoceptor; ligand-gated ion channel purinergic receptor P2X1; P2X purinoceptor 1 P2X1 (P2RX1, P2X1)

Function

• ligand-gated ion channel with high Ca+2 permeability
• binding of ATP mediates
  • synaptic transmission between neurons
  • transmission from neurons to smooth muscle
• may be linked to apoptosis via increasing intracellular Ca+2

Structure

• homo- or heteropolymers (putative)
• belongs to the P2X receptor family

Compartment

membrane

Pathology

• defects in P2RX1 are a cause of bleeding disorder(s)

More general terms

• transmembrane 2 protein
• P2X purinoceptor or P2X purinergic receptor

Database

• OMIM: https://mirror.omim.org/entry/600845
• UniProt: http://www.uniprot.org/uniprot/P51575.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5023