chloride intracellular channel protein 2; XAP121 (CLIC2)

Function

• can insert into membranes & form chloride ion channels
• channel activity depends on the pH
• membrane insertion seems to be redox-regulated & may occur only under oxidizing conditions
• modulates the activity of RYR2 & inhibits Ca+2 influx
• monomer, interacts with TRAPPC2 & RYR2

Structure

• members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane & functions as chloride channel
• a conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion
• belongs to the chloride channel CLIC family
• contains 1 GST C-terminal domain

Compartment

• cytoplasm, membrane
• single-pass membrane protein (probable)
• exists both as soluble cytoplasmic protein & as membrane protein with probably a single transmembrane domain

Expression

• expressed in adult brain, heart, liver, lung, spleen, stomach & testis
• expressed in fetal liver & adult skeletal muscle

More general terms

• chloride intracellular channel protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1193
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1193
• OMIM: https://mirror.omim.org/entry/300138
• UniProt: http://www.uniprot.org/uniprot/O15247.html