K+ voltage-gated channel subfamily G member 2; cardiac K+ channel subunit; voltage-gated K+ channel subunit Kv6.2 (KCNG2, KCNF2)

Function

• K+ channel subunit
• modulates channel activity by shifting the threshold & the half-maximal activation to more negative values
• heterodimer with KCNB1
• does not form homomultimers

Structure

• the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
• belongs to the K+ channel family, G (TC 1.A.1.2) subfamily, Kv6.2/KCNG2 sub-subfamily

Compartment

membrane

Expression

• highly expressed in heart, liver, skeletal muscle, kidney & pancreas
• detected at low levels in brain, lung & placenta

Notes

• heterodimers with KCNB1 are highly sensitive to inhibition by tetraethylammonium (TEA) & propafenone

More general terms

• K+ channel subfamily G
• transmembrane 6 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26251
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26251
• OMIM: https://mirror.omim.org/entry/605696
• UniProt: http://www.uniprot.org/uniprot/Q9UJ96.html