K+ channel subfamily K member 6; inward rectifying K+ channel protein TWIK-2; TWIK-originated similarity sequence (KCNK6, TOSS, TWIK2)

Function

• outward rectification with physiological K+ gradient
• mild inward rectification with symmetrical K+ conditions

Structure

• homodimer (putative)
• belongs to the two pore domain K+ channel (TC 1.A.1.8) family

Compartment

membrane (potential)

Alternative splicing

named isoforms=2

Expression

• widespread expression
• detected in all tissues tested except for skeletal muscle
• strongest expression in placenta, pancreas, heart, colon & spleen
• lower levels in peripheral blood leukocytes, lung, liver, kidney & thymus
• lowest expression in brain

Notes

• inhibited by internal acidification &, to a small degree, by Zn+2
• not inhibited by quinine, quinidine or Ba+2

More general terms

• K+ channel subfamily K
• glycoprotein
• transmembrane 4 protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9Y257.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9424
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9424
• OMIM: https://mirror.omim.org/entry/603939