inward rectifier K+ channel 13; K+ channel, inwardly rectifying subfamily J member 13; inward rectifier K+ channel Kir7.1 (KCNJ13)

Function

• inwardly-rectifying K+ channel
• very low single channel conductance
• low sensitivity to block by external Ba+2 & Cs+2
• no dependence of its inward rectification properties on the internal blocking particle Mg+2

Structure

• belongs to the inward rectifier-type K+ channel family

Compartment

membrane

Expression

• predominantly expressed in small intestine
• expression is also detected in stomach, kidney, & central nervous system
• not expressed in spinal cord

Pathology

• defects in KCNJ13 are the cause of snowflake vitreoretinal degeneration

More general terms

• inwardly-rectifying K+ channel subfamily J
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/O60928.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3769
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3769
• OMIM: https://mirror.omim.org/entry/193230
• OMIM: https://mirror.omim.org/entry/603208