cystatin 1 (cystatin-SN, salivary cystatin-SA-1, CST1)

Function

• one of several cysteine proteinase inhibitors immunologically related to cystatin S
• cystatin SN, with a pI of 7.5, is a much better inhibitor of papain & dipeptidyl peptidase-1 than is cystatin S
• both inhibit ficin equally well

Structure

belongs to the cystatin family

Compartment

secreted

Expression

found in saliva, tears, urine & seminal fluid

More general terms

• cystatin

Database

• UniProt: http://www.uniprot.org/uniprot/P01037.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1469
• OMIM: https://mirror.omim.org/entry/123855
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1469