CD32; low affinity immunoglobulin gamma Fc region receptor II-c; IgG Fc receptor II-c; Fc-gamma RII-c; Fc-gamma-RIIc; FcRII-c; CDw32 (FCGR2C, FCG2, IGFR2)

Function

• receptor for the Fc region of complexed IgG, low affinity receptor
• role in effector & regulatory functions including:
  • phagocytosis of immune complexes
  • modulation of antibody production by B-cells

Structure

• contains 2 ITAM motifs
• contains 2 Ig-like C2-type domain (immunoglobulin-like)

Compartment

• isoforms IIC1 IIC2, IIC3: cell membrane
• isoform IIC4: cytoplasm (probable)

Alternative splicing

named isoforms=4

Expression

• isoform IIC1 is detected in monocytes, macrophages, neutrophils & natural killer cells

More general terms

• CD32 or Fc gamma [IgG] receptor-II (low affinity)
• phosphoprotein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9103
• UniProt: http://www.uniprot.org/uniprot/P31995.html