leukocyte immunoglobulin-like receptor subfamily B member 5; leukocyte immunoglobulin-like receptor 8; LIR-8; CD85 antigen-like family member C; CD85c (LILRB5, LIR8)
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Function
- may act as receptor for class 1 MHC antigens
Structure
- contains 2 ITIM motifs
- phosphorylated ITIM motif can bind the SH2 domain of several SH2 domain-containing phosphatases
- contains 4 Ig-like C2-type domains (immunoglobulin-like)
Compartment
- membrane; single-pass type 1 membrane protein
Alternative splicing
named isoforms=3
Expression
detected in a natural killer (NK) cells
Pathology
- variant rs12975366: T > C Asp247Gly associated with lower serum creatine kinase & serum lactate dehydrogenase & with statin myopathy[2]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/O75023.html
- ↑ 2.0 2.1 Siddiqui MK, Maroteau C, Veluchamy A et al A Common Missense Variant of LILRB5 Is Associated With Statin Intolerance and Myalgia. Eur Heart J. 2017;38(48):3569-3575 Medscape. March 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29020356 Free PMC Article https://www.medscape.com/viewarticle/891063