flavoprotein monooxygenase 6; dimethylaniline monooxygenase [N-oxide forming] 6; hepatic flavin-containing monooxygenase 6 (FMO6, FMO6P)

Function

• oxidation of amines (putative)

Cofactor: FAD (putative)

Structure

belongs to the FMO family

Compartment

• microsome membrane (putative)
• endoplasmic reticulum membrane (putative)

Expression

• probably only produced in very small quantity or not at all as the gene coding for it seems to be unable to produce full length transcripts

Polymorphism

• two alleles; one major, FMO6X105 (truncated form) & one minor, FMO6Q105, (full-length form similar to the protein found in other mammals)
• a nonsense mutation transforms the Gln-105 into a premature stop codon
• the truncated protein is catalytically inactive

More general terms

• flavoprotein mixed function oxidase

Database

• UniProt: http://www.uniprot.org/uniprot/O60774.html