cytochrome P450 2U1 (CYP2U1)

Function

• catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid & other long chain fatty acids
• may modulate the arachidonate cascade & play a role in other fatty acid signaling processes

RH + reduced flavoprotein + O2
               <-->
ROH + oxidized flavoprotein + H2O

Kinetic parameters

• KM=2.7 uM for arachidonic acid

Structure

belongs to the cytochrome P450 family

Compartment

endoplasmic reticulum membrane

Alternative splicing

named isoforms=2

Expression

• widely expressed
• strong expression in thymus, heart & cerebellum
• expressed in fetal thymus

More general terms

• cytochrome P450
• transmembrane 5 protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q7Z449.html