cytochrome P450 2R1 (vitamin D 25-hydroxylase, CYP2R1)

Function

• D-25-hydroxylase activity on vitamin D2 & D3

Kinetic parameters:

• KM=0.67 uM for vitamin D2
• KM=0.45 uM for vitamin D3

Structure

belongs to the cytochrome P450 family

Compartment

• endoplasmic reticulum membrane
• peripheral membrane protein, microsome membrane

Pathology

• mutations associated with 25-hydroxyvitamin D3 deficiency (pseudovitamin D3 deficiency rickets) due to vitamin D 25-hydroxylase deficiency

More general terms

• cytochrome P450

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1202
• OMIM: https://mirror.omim.org/entry/608713
• OMIM: https://mirror.omim.org/entry/600081
• UniProt: http://www.uniprot.org/uniprot/Q6VVX0.html