cytochrome P450 2F1 (CYP2F1)

Function

• dealkylation of
  • ethoxycoumarin, propoxycoumarin, pentoxyresorufin
  • no activity toward ethoxyresorufin
  • trace activity toward benzyloxyresorufin
• bioactivates 3-methylindole (3MI) by dehydrogenation to electrophilic 3-methylene-indolenine

Structure

belongs to the cytochrome P450 family

Compartment

membrane-bound, endoplasmic reticulum

More general terms

• cytochrome P450

Database

• UniProt: http://www.uniprot.org/uniprot/P24903.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1572
• OMIM: https://mirror.omim.org/entry/124070
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1572