phosphohexose isomerase (PHI, phosphoglucose isomerase, PGI, phosphofructose isomerase, neuroleukin, NLK)
Jump to navigation
Jump to search
Function
- catalyzes conversion of glucose-6-phosphate to fructose-6-phosphate
- neuroleukin is a neurotrophic factor for spinal & sensory neurons
- carbohydrate degradation; glycolysis
- D-glyceraldehyde 3- phosphate & glycerone phosphate from D-glucose, step 2/4
D-glucose 6-phosphate <--> D-fructose 6- phosphate
Structure
- homodimer
- belongs to the GPI family
Compartment
Pathology
- defects in GPI are a cause of hereditary nonspherocytic hemolytic anemia
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P06744.html
- ↑ SHMPD; The Singapore human mutation & polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=GPI
- ↑ Wikipedia; phosphoglucose isomerase entry http://en.wikipedia.org/wiki/phosphoglucose_isomerase