phosphohexose isomerase (PHI, phosphoglucose isomerase, PGI, phosphofructose isomerase, neuroleukin, NLK)

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Function

  • catalyzes conversion of glucose-6-phosphate to fructose-6-phosphate
  • neuroleukin is a neurotrophic factor for spinal & sensory neurons
  • carbohydrate degradation; glycolysis
  • D-glyceraldehyde 3- phosphate & glycerone phosphate from D-glucose, step 2/4
D-glucose 6-phosphate <--> D-fructose 6- phosphate

Structure

  • homodimer
  • belongs to the GPI family

Compartment

cytoplasm

Pathology

More general terms

Additional terms

References

  1. UniProt http://www.uniprot.org/uniprot/P06744.html
  2. SHMPD; The Singapore human mutation & polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=GPI
  3. Wikipedia; phosphoglucose isomerase entry http://en.wikipedia.org/wiki/phosphoglucose_isomerase

Database