peroxisomal carnitine O-octanoyltransferase (COT, CROT)

Function

• beta-oxidation of fatty acids
• highest activity with C6-C10 chain length substrate
• converts end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester

Octanoyl-CoA + L-carnitine <--> CoA + L-octanoylcarnitine

Structure

• monomer
• belongs to carnitine/choline acetyltransferase family

Compartment

• peroxisome

More general terms

• transferase

Database

• OMIM: https://mirror.omim.org/entry/606090
• UniProt: http://www.uniprot.org/uniprot/Q9UKG9.html