cytosolic acyl coenzyme A thioester hydrolase; acyl-CoA thioesterase 7; brain acyl-CoA hydrolase; CTE-IIa; CTE-II; long chain acyl-CoA thioester hydrolase (ACOT7, BACH)

Function

• acyl-CoA thioesterases are a group of enzymes that catalyze hydrolysis of acyl-CoAs to the free fatty acid & coenzyme A, thus may regulate intracellular levels of acyl-CoAs, free fatty acids & coenzyme A
• may a role in brain
• may play a regulatory role by modulating the cellular levels of fatty acyl-CoA ligands for certain transcription factors as well as thesubstrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis
• broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18
• maximal activity toward palmitoyl-CoA
• homodimer (probable)

Structure

• contains 2 acyl coenzyme A hydrolase domains

Compartment

• isoform 1: mitochondria
• isoform 4: cytoplasm
• isoform 5: mitochondria
• isoform 6: cytoplasm

Alternative splicing

named isoforms=6

Expression

• isoform 4 is expressed exclusively in brain

More general terms

• hydrolase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11332
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11332
• OMIM: https://mirror.omim.org/entry/602587
• UniProt: http://www.uniprot.org/uniprot/O00154.html