trans-2-enoyl-CoA reductase, mitochondrial; nuclear receptor-binding factor 1; HsNrbf-1; NRBF-1 (MECR, NBRF1, CGI-63)

Function

• catalyzes reduction of trans-2-enoyl-CoA to acyl-CoA with chain length C6-C16
• mitochondrial synthesis of fatty acids (putative)

Acyl-CoA + NADP(+) <---> trans-2,3-dehydroacyl-CoA + NADPH

Kinetic parameters

• KM=37 uM for trans-2-hexenoyl-CoA
• KM=7.1 uM for trans-2-decenoyl-CoA

Structure

homodimer

Compartment

mitochondria

Expression

• expressed in skeletal muscle, heart muscle > placenta, liver, kidney, pancreas > lung

More general terms

• oxidoreductase
• mitochondrial protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51102
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51102
• OMIM: https://mirror.omim.org/entry/608205
• UniProt: http://www.uniprot.org/uniprot/Q9BV79.html