pyridoxine-5'-phosphate oxidase; pyridoxamine-phosphate oxidase (PNPO)

Function

• catalyzes oxidation of either pyridoxine-5'-phosphate or pyridoxamine-5'-phosphate into pyridoxal-5'-phosphate (PLP)
• cofactor biosynthesis; vitamin B6 interconversion; pyridoxal-5'-phosphate from pyridoxamine-5'-phosphate pyridoxal-5'-phosphate from pyridoxine-5'-phosphate

pyridoxamine-5'-phosphate + H2O + O2 = pyridoxal-5'-phosphate + NH3 + H2O2

pyridoxine-5'-phosphate + O2 = pyridoxal-5'-phosphate + H2O2

Cofactor: binds 1 FMN per subunit

Structure

• belongs to the pyridoxamine 5'-phosphate oxidase family

Pathology

• defects in PNPO are the cause of pyridoxine-5'-phosphate oxidase deficiency

More general terms

• oxidoreductase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55163
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55163
• OMIM: https://mirror.omim.org/entry/603287
• OMIM: https://mirror.omim.org/entry/610090
• UniProt: http://www.uniprot.org/uniprot/Q9NVS9.html