C-4 methylsterol oxidase; methylsterol monooxygenase (SC4MOL, DESP4, ERG25, MSMO1)

Function

• enzyme of cholesterol biosynthesis
• steroid biosynthesis; zymosterol biosynthesis
• zymosterol from lanosterol: step 3/6

Cofactor: iron (probable)

Structure

• 3 transmembrane domains
• the histidine box domains may contain the active site &/or be involved in metal ion binding
• belongs to the sterol desaturase family

Compartment

• endoplasmic reticulum membrane
• multi-pass membrane protein (probable)

More general terms

• oxidoreductase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6307
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6307
• OMIM: https://mirror.omim.org/entry/607545
• UniProt: http://www.uniprot.org/uniprot/Q15800.html