spondin-2 (Mindin, differentially expressed in cancerous & non-cancerous lung cells 1, DIL-1, SPON2, DIL1, UNQ435/PRO866)

Function

• cell adhesion protein
• promotes adhesion & outgrowth of hippocampal embryonic neurons
• binds directly to bacteria & their components
• functions as an opsonin for macrophage phagocytosis of bacteria
• essential in the initiation of the innate immune response
• unique pattern-recognition molecule in the extracellular matrix for microbial pathogens

Compartment

secreted, extracellular matrix

Expression

• expressed in normal lung tissues but not in lung carcinoma cell lines

More general terms

• spondin
• cell adhesion protein

Database

• OMIM: https://mirror.omim.org/entry/605918
• UniProt: http://www.uniprot.org/uniprot/Q9BUD6.html