heat shock 70 kD protein 6; heat shock 70 kD protein B' (HSPA6, HSP70B')

Function

• in cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation & mediate folding of newly translated polypeptides in the cytosol as well as within organelles
• recognition of nonnative conformations of other proteins
• binds extended peptide segments with a net hydrophobic character exposed by polypeptides during translation & membrane translocation, or following stress-induced damage

Structure

belongs to the heat shock protein 70 family

Expression

only at higher temperatures, & no basal expression

More general terms

• heat shock protein [hsp]-70 family

Database

• UniProt: http://www.uniprot.org/uniprot/P17066.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3310
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3310
• OMIM: https://mirror.omim.org/entry/140555