plakophilin-3 (PKP3)

Function

• may play a role in junctional plaques

Structure

• belongs to the beta-catenin family
• contains 8 ARM repeats

Compartment

• nucleus, cell junction, desmosome
• nuclear & associated with desmosomes

Expression

• found in desmosomes of most simple and stratified epithelia
• not found in foreskin fibroblasts & various sarcoma-derived cell lines
• found in dendritic reticular cells of lymphatic follicles
• not found in other non-epithelial desmosome-bearing tissues

More general terms

• plakophilin
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11187
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11187
• OMIM: https://mirror.omim.org/entry/605561
• UniProt: http://www.uniprot.org/uniprot/Q9Y446.html