small proline-rich protein 4 (SPRR4)
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Function
- cross-linked envelope protein of keratinocytes
- role in UV-induced cornification
- cross-linked to membrane proteins by transglutaminase (probable)
Structure
belongs to the cornifin (SPRR) family
Compartment
- cytoplasm, cell cortex -translocates to the cell periphery of keratinocytes & is integrated into both rigid & fragile cornified envelopes
Expression
induced by UV light