integrin alpha-11 (ITGA11)

Function

• associates with integrin beta-1 (integrin alpha-11/beta-1)

Structure

• integrin I-domain (insert) is a VWFA domain
• integrins with I-domains do not undergo protease cleavage
• belongs to the integrin alpha chain family
• contains 7 FG-GAP repeats
• contains 1 VWFA domain

Compartment

membrane

Expression

• expressed in uterus, heart > skeletal muscle > pancreas, kidney & placenta
• also found in brain, colon, lung, small intestine, stomach, testis, salivary glands, thyroid glands & prostate
• very low levels in peripheral blood lymphocytes, fetal brain & fetal liver
• strongly up-regulated in differentiating fetal muscle cells (in vitro)

More general terms

• integrin-alpha

Component of

• integrin alpha-11/beta-1

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2280
• OMIM: https://mirror.omim.org/entry/604789
• UniProt: http://www.uniprot.org/uniprot/Q9UKX5.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22801