integrin alpha-10 (ITGA10)

Function

• associates with integrin beta-1 (integrin alpha-10/beta-1)

Structure

• the integrin I-domain (insert) is a VWFA domain
• integrins with I-domains do not undergo protease cleavage
• belongs to the integrin alpha chain family
• contains 7 FG-GAP repeats
• contains 1 VWFA domain

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• widely expressed
• highest expression in muscle & heart
• found in articular cartilage

More general terms

• integrin-alpha

Component of

• integrin alpha-10/beta-1

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8515
• OMIM: https://mirror.omim.org/entry/604042
• UniProt: http://www.uniprot.org/uniprot/O75578.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8515