NF-kappa-B inhibitor-like protein 2; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2; I-kappa-B-related protein; IkappaBR (NFKBIL2, IKBR, TONSL)

Function

• role in the regulation of NF-kappa-B transcription factor complexes
• acts either as a negative or positive regulator of NF-kappa-B mediated activation of transcription

Structure

• contains 3 ANK repeats
• contains 7 LRR repeats (leucine-rich repeats)
• contains 8 TPR repeats

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• expressed in heart, skeletal muscle & tracheal epithelial cells

More general terms

• ankyrin repeat domain protein (ANKRD)

Database

• OMIM: https://mirror.omim.org/entry/604546
• UniProt: http://www.uniprot.org/uniprot/Q96HA7.html