ristocetin cofactor activity
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Clinical significance
- ristocetin-induced agglutination of platelets requires a cofactor found in serum
- that cofactor is von-Willebrand's factor (vWF)
Decreases
Methods
- freshly washed or formalin fixed aggregation of normal platelets induced by ristocetin in the presence of patient serum is generally considered a sensitive indicator of vWF functional activity
- less sensitive techniques involve platelet aggregation studies after direct addition of ristocetin to patient platelet-rich plasma.
Specimen
More general terms
Additional terms
- ristocetin
- von Willebrand factor; vWF; ristocetin cofactor; factor VIII related antigen; contains: von Willebrand antigen 2 (VWF, F8VWF)
Component of
References
- ↑ Clinical Diagnosis & Management by Laboratory Methods, 19th ed. J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 732
- ↑ Panel of 4 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0030002.jsp
- ↑ Panel of 3 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0030125.jsp
- ↑ Von Willebrand Factor, Activity (RCF) Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0030250.jsp
- ↑ Mini Panel of 2 tests: Von Willebrand Factor, Activity (RCF) . Von Willebrand Factor, Antigen Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0030284.jsp
- ↑ Panel of 3 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0000000.jsp
- ↑ Panel of 7 tests Laboratory Test Directory ARUP: http://www.aruplab.com/guides/ug/tests/0000000.jsp