CUG-BP-& ETR-3-like factor 4 (CELF-4, Bruno-like protein 4, RNA-binding protein BRUNOL-4, BRUNOL4, CELF4)

Function

• RNA-binding protein
• role in regulation of pre- mRNA alternative splicing
• mediates exon inclusion &/or exclusion in pre-mRNA subject to tissue-specific & developmentally regulated alternative splicing
• specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition
• promotes exclusion of both smooth muscle & non-muscle exons in actinin pre-mRNAs
• binds to muscle-specific splicing enhancer intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA

Structure

• belongs to the CELF/BRUNOL family
• contains 3 RRM (RNA recognition motif) domains

Compartment

nucleus, cytoplasm

Alternative splicing

named isoforms=5

Expression

• ubiquitou
• strongly expressed in cerebellum, hippocampus, amygdala, temporal cortex, frontal cortex, frontal lobes

More general terms

• CUG-BP- & ETR-3-like factor

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BZC1.html